IN VIVO HEPATOPROTECTIVE ACTIVITY OF RICINUS COMMUNIS. LINN LEAF EXTRACT AGAINST CCl4 INDUCED HEPATIC DAMAGE IN ALBINO RATS
The present study aims to investigate the hepatoprotective activity of the ethanolic leaf extract of Ricinus communis against carbon tetra chloride (Ccl4) induced hepatotoxicity in albino rats. Two different doses of Ricinus communis leaf extract were administered orally for 5 days. The hepatoprotective activity was studied in liver by measuring the parameters like serum levels of Glutamic oxaloacetate transaminase (SGOT), Glutamic pyruvic transaminase(SGPT), Bilirubin, Alkaline phosphatase(ALP) and histological changes in liver of different groups of animals were observed. Ethanolic leaf extract of Ricinus communis has reduced all biochemical parameters in comparison with silymarin. The protective effect of the extract on Ccl4 induced damage was confirmed by histopathological examination of the liver. The results were strongly supports the protective effect of ethanolic leaf extract of Ricinus communis against acute liver injury.