PROTECTIVE ACTION OF FLAVONOIDS EXTRACTED FROM DIFFERENT JORDANIAN PLANTS AGAINST OXIDATIVE STRESS
Oxidative stress represents a potential health risk. Prevention of such possible risks in human and animals is of great importance. To date, however, there is no effective treatment of acute tissue injury induced by free radicals. Understanding the mechanism of free radicals damage is beneficial and critical to plan new strategies in order to reduce its effects. In this study three compounds from Jordanian plants were chosen as a source of flavonoids; Hesperidin, Naringin and Silymarin extracts were identified and quantified. The radical scavenging activities of the selected flavonoids were determined using the haemolysis of human Red Blood Cells mediated by Ferrous Sulfate. This work highlights the importance of Hesperidin, Naringin and Silymarin protective action against oxidative stress as supported by biochemical results. Moreover the study indicates that Silymarin has the highest protective capacity against free radicals damage followed by Naringin and Hesperidin respectively. As a result of this work, combined with our previous studies, we now confirm that the protective effect of Hesperidin, Naringin and Silymarin could provide a new insight into the potential therapeutic solution to free radicals induced cell injury.