INCLUSION COMPLEX OF DEXIBUPROFEN AND IT’S IN VITRO AND IN VIVO EVALUATION
Dexibuprofen, a poorly water-soluble nonsterodial anti-inflammatory drug has better anti-inflammatory effect than Ibuprofen. The aqueous solubility and dissolution rate of Dexibuprofen (DI) with β-cyclodextrin (β-CD) was investigated. The Dexibuprofen was complexed with β-CD in 1:1and 1:2 ratio by freeze drying and kneading method. The aqueous solubility of Dexibuprofen was determined by phase solubility method. The inclusion complexes were prepared and characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry techniques (DSC). FTIR spectra and DSC thermograph of Dexibuprofen, β-CD, and Dexibuprofen-β-CD (DI-β-CD) complexes indicate there is no chemical interaction and confirmed the stability of the drug with its complex. The invivo analgesic activity by Tail-flick and Eddy’s hot plate method and anti-inflammatory activity by paw edema method were performed. Invitro studies showed that the solubility and dissolution rate of Dexibuprofen were significantly improved by complexation with β-cyclodextrin. In contrast, freezedried complexes showed higher dissolution rate than the other complexes and better analgesic and anti-inflammatory activity with respect to the drug alone.