UV- SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND ONDANCETRON IN BULK AND THEIR FORMULATION
A simple, accurate, validated and reproducible UV-spectrophotometric method has been developed for the simultaneous estimation of Paracetamol and Ondancetron in both bulk and tablet formulation. Paracetamol and Ondancetron in combined tablet formulation were estimated by using the multicomponent mode at 248nm for Paracetamol and 267nm for Ondancetron in their solution in methanol: double distilled water (9:1). The Beer’s law obeyed the concentration range of 2-20 µg/ml for Paracetamol and 0.1-1 µg/ml for Ondancetron. Mean recovery of 99.36% for Paracetamol and 99.99% for Ondancetron respectively signifies the accuracy of the method. This method can be used for the routine simultaneous estimation of Paracetamol and Ondancetron in industries and other analytical laboratories.