INVIVO EVALUATION OF GASTRO RETENTIVE FLOATING MICROSPHERE CONTAINING REBEPRAZOLE SODIUM
The present study was aimed to Invivo evaluation of gastro retentive floating microsphere containing Rabeprazole sodium. Rabeprazole sodium microsphere was prepared by the solvent evaporation method using polymers HPMC, EC & Chitosan. In vitro drug release studies were obtained for floating microsphere of RS showed good incorporation efficiency, good buoyancy and prolonged drug release. The data obtained for floating microsphere of formulation 3 showed excellent floatability. The higher polymer to drug ratio improved the entrapment efficiency, percentage yield, as well as buoyancy percentage. Stability studies were performed for the prepared formulations and the results showed good stability. Peptic ulcer occurs due to an imbalance between the aggressive (acid, pepsin and Helicobacter pylori) and the defensive (gastric mucus and bicarbonate secretion, prostaglandins, innate resistance of the mucosal cells) factors. Number of drugs including proton pump inhibitors, prostaglandins analogs, histamine receptor antagonists and cytoprotective agents are available for the treatment of peptic ulcer. But most of these drugs produce several adverse reactions including toxicities and even may alter biochemical mechanisms of the body upon chronic usage. It has been proposed that in ethanol induced ulcer model, ulcers are developed due to accumulation of gastric acid and pepsin, which leads to auto-digestion of gastric mucosa. The Anti-ulcer property of RS is evident from its significant reduction in free acidity, total acidity and ulcer index. Histopathological studies were also confirming the potent activity for F3. It has been concluded that the best formulation of Rabeprazole sodium has significant and extended anti-ulcer activity when compared with marketed drug.