IN VIVO EVALUATION OF GASTRORETENTIVE FLOATING DELIVERY SYSTEM OF CEFDINIR
A novel floating controlled release drug delivery system of Cefdinir was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. The present work investigates the In vivo buoyancy, bioavailability and in vivo pharmacological activity of prepared floating tablets of cefdinir as model drug delivery system. The floating tablets were prepared with modified gum karaya by wet granulation technique. The best formulation was selected based on in vitro characteristics and was used in vivo radiographic studies by incorporating BaSO4. Buoyancy was achieved by adding an effervescent mixture of sodium bicarbonate and anhydrous citric acid. The In vivo buoyancy study was performed in beagle dogs to evaluate intra-gastric retention performance in different time intervals by X-ray radiographic method. Followed by the floating tablets were evaluated for its bioavailability activity in white albino rabbits by the floating tablets showed better bioavailability characteristic. A level of correlation was established from the obtained results. Thus, the formulation has the potential to liberate drugs by following Fickian diffusion mechanism having good degree of In vitro and In vivo correlation. The floating formulation shows excellent buoyancy and better gastric cytoprotection when compared with conventional dosage form