IMPACT OF ALCOHOL ON RAT HEART AND ENDOTHELIAL CELLULAR FREE Ca2+ AND cGMP LEVELS IN VITRO AND IN VIVO
Calcium (Ca2+) plays a vital role in the regulation of many in physiological events in cell and organs including fertilization, cell growth, muscle growth, muscle contraction, neuronal signal transduction and bile flow. The observed data indicated that both the heart and ET Cellular soluble fractions Ca2+ levels were lowerd by the alcohol in selected concentrations, and because the alcohol lowered Ca2+ levels of the samples tested was below 160 nM, it is concluded that this much Ca2+ level would fail to estimate the NOS activity of the heart as well ET Cellular fractions. As NOS stimulation leads to rise the cGMP levels of ET which intrun becomes responsible for the production of NO and there by leads to vasodilatation, the author attempted to study the cGMP levels of heart and ET cellular preparations under alcoholic stress. The results indicated (Table: 1-2) an inhibited trend of the alcohol treated samples Ca2+/ cGMP levels