TYPHA ANGUSTATA LEAF EXTRACT AMELIORATES PHENOTHIAZINE INDUCED CATATONIA IN WISTAR RATS
Typical antipsychotics drugs like phenothiazine like chlorpromazine or perphenazine and haloperidol will produce extra pyramidal side effects (catatonic symptoms) like tremors, muscular rigidity and bradykinesia. Due to presence of low level of dopamine, g-amino butyric acid (GABA) and high levels of glutamate in brain phenothiazines produces catatonia symptoms in humans and animals. So that the present study was undertaken to investigate the anticatatonic effect of methanolic leaf extract of Typha angustata in wistar rats. The extract at the dose of 100 mg/kg body weight has shown significant anticatatonic activity by reducing the extra pyramidal side effects like tremors, muscular rigidity, bradykinesia (slowness in initiating and carrying out voluntary movements). These results suggest that the methanolic extract of Typha angustata possess significant anticatatonic effect (p < 0.01) when compared to the other groups