FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC PUMP OF PROPRANOLOL HYDROCHLORIDE
In present study the controlled porosity osmotic pump (CPOP) of propranolol hydrochloride (PHC) was developed. Propranolol hydrochloride is desirable candidate of CPOP as it is a BCS class I drug and have short half life of 3-6 hour. The effect of different formulation variable, namely, concentration of pore former (PEG 4000), plasticizer (castor oil), membrane weight gain, pH and agitation on the in vitro release was studied to optimized release profile of Propranolol hydrochloride. The Propranolol hydrochloride release was directly proportional to % pore former and inversely proportional to amount of plasticizer (castor oil) and % weight gain. The drug release of optimized formulation (P4) was independent of pH and agitation intensity for 12 hour. The comparative study of marketed product (BETACAP TR 60mg Capsule) and controlled porosity osmotic pump was studied and similarity factor (f2) value 33.68 was found with marketed product. So, it revealed that optimized tablet have better controlled release than marketed product with 12 hr releases study. Developed formulations were found to be stable after 3 month of storage