FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF SAXAGLIPTIN
The present work aimed at formulation and evaluation of a taste masked Fast dissolving tablets of Saxagliptin. Saxagliptin is an anti-diabetic drug which belongs to BCS Class III drug, having a bad and metallic taste. So by formulating it as fast dissolving tablet the absorption and the bioavailability of the drug will fasten and hence the action of the drug will be faster. The mode of action of Saxagliptin is mainly by inhibition of dipeptidyl peptidase enzyme. Three superdisintegrants were used namely sodium starch glycolate, crospovidone, crosscarmellose sodium in combination with Kollidon CL, as novel super disintegrant and Pearlitol as a taste masking agent. The tablets were formulated and evaluated for various parameters like weight variation, hardness, friability, drug content, disintegration and in vivo dissolution. Among all the formulations F5 showed 99% drug release within 15 min. So it was considered as best formulation. Finally stability studies were done for the F5 formulation as per the ICH guidelines at 40º C & 75 % RH for 3 months and there are no changes in the drug content, disintegration, in vitro dissolution