COMPARATIVE HOMOLOGY MODELING OF HUMAN PGLYCOPROTEIN
Multidrug resistance is a condition in which disease causing organisms become resistant to different drugs or chemicals of large variety related to structure or function. Multidrug resistance is a common problem not only involved in cancer but also in many infectious diseases related to different organisms including human. Homology modelling is the method in which 3D model of target which is generally protein is generated from their sequences using a homologous protein which acts as template. Till now the complex structure of human P-glycoprotein is not solved successfully by NMR or X-ray crystallography so in the present investigation 4 online servers including Esypred3D,Homer, Swiss Model,Phyre2 and 1 software named EasyModeller is used to generate 22 homology models of human P-gp which will be further useful in developing inhibitors and drugs for human P-gp