e -Issn : 0976 - 3651
Print-Issn : 2229-7480

  ABSTRACT

EFFECT OF CAMEL MILK ON HEPATIC ANTIOXIDANT ENZYMES IN RABBITS INTOXICATED WITH CARBON TETRACHLORIDE

A total of 20 rabbits was divided into four equal groups to investigate the protective effects of camel milk on some antioxidant enzymes and biochemical parameters in normal (non- CCl4-induced hepatic injury) and CCl4-induced hepatic injury rabbits. A dose of 40 mL/kg body weight of camel milk was orally administered daily to normal and CCl4-induced hepatic injury rabbits for 14 days. At the end of the experiment, blood samples were collected and the harvested sera and plasma were used for determination of liver injuries biomarkers enzymes. The present findings CCl4 challenge reduced plasma GlutathioneS-Transferase and Catalase activities and elevated serum Alanine, Aspartate Aminotransferase Alkaline Phosphatase, Creatinine, blood urea nitrogen, Triglycerides and Cholesterol, but these effects were prevented by the treatment of rabbits with camel milk. The present study concluded that camel milk caused protective effect against CCl4-induced liver damage, augmenting antioxidant defense system at activity, and enhancing liver enzyme activities. Therefore, our study, aimed to confirm the protective effects of camel milk against CCl4- induced hepatotoxicity in rabbits by assaying antioxidant enzymes , liver and kidney functions and lipid profiles

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