NHIBIT OF HUMULUS JAPONICUS EXTRACTION FOR THE ACTIVITY OF ANGIOTENSIN CONVERTING ENZYME
Angiotensin-converting enzyme (ACE, EC 3.4.15.1) indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibition has become a major target control for hypertension. The research on potential ACE inhibitors is expanding broadly and most are focused on natural product derivatives. The aim of the current study was to isolate and characterizer the constituents responsible of the ACE activity of the aqueous extract of Humulus japonicas and to compare needle extractions of Pinus densiflora, and Juniperus chinensis.The isolated compounds were characterized by spectroscopic methods. The leaves of H. japonicas demonstrated ACE inhibitory activity at a concentration of 500 μg/ml, showing an inhibition greater than 50%. These compounds showed similar effects to those obtained by related captopril. The leaves extraction for ACE inhibitor was more effective than stems extraction. The results of this study suggest that the leaf extract of H. japonicas has significant ACE inhibitory effect