STUDY ON PHYTOCHEMICAL PROFILE AND ANTI-EPILEPTIC ACTIVITY OF OXALIS CORNICULATA L.
The present study was performed to evaluate the antiepileptic activity of methanol extract of leaves of Oxalis corniculata L. (MEOC) was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. Acute toxicity of extract was non toxic up to the recommended dose 2000mg/kg body weight orally as per OECD guidelines No.423. Animals were pretreated with MEOC at the doses of 200 and 400mg/kg body weight. In MES model, MEOC showed significant reduction in duration of hindleg extension with 200 mg/kg dose and effect was dramatically reduced with 400mg/kg. Similar dose dependent results were obtained in PTZ model by delayed the onset of clonic convulsions. The complete protective effect against mortality was reported in both the tests. In conclusion, our present results indicate that Oxalis corniculata L. has antiepileptic effects on MES- and PTZ induced convulsions and its mechanisms might relate to potentiation of the activity of GABA receptors and their signal transduction process