ANTIHYPERTENSIVE ACTIVITY OF SESBANIA GRANDIFLORA LEAVES ON RENAL ARTERY OCCLUSION INDUCED HYPERTENSION IN RATS
The objective of the study was to evaluate the effect of ethanolic leaf extract of Sesbania grandiflora on renal artery occlusion induced hypertension in rats. The animals were divided in to five groups of six animals each. 0.1% Carboxy Methyl Cellulose was used as vehicle. Sesbania grandiflora leaf extract was used at two dose levels of 200 and 400 mg/kg. Ramipril was used as reference control. Hypertension was induced by occluding the renal artery in rats and the test drugs were administered for 14 days. At the end of the study, mean blood pressure was recorded in all the groups using BIOPAC student lab data acquisition system. Increased in the blood pressure in the untreated groups indicate renal artery occlusion induced hypertension. Pretreatment with Sesbania grandiflora (200 and 400 mg/kg) showed significant (P<0.05 and P<0.01) decrease in blood pressure in the hypertension induced rats respectively. The antihypertensive effect of Sesbania grandiflora showed equipotent activity as that of the reference control Ramipril. The results showed that, the ethanolic leaf extract of Sesbania grandiflora exhibited antihypertensive activity against renal artery occlusion induced hypertension in rats