PROTECTIVE EFFECT OF GINGER EXTRACT AGAINST CISPLATIN INDUCED NEPHROTOXICITY IN RATS
Nephrotoxicity was reported in the initial clinical trials of cisplatin chemotherapy.Our study was designed to evaluate the nephroprotective effect of Ginger extract promoted by cisplatin.Animalswere divided into7 groups as follow: Group1 (Control): Animals were injected intraperitoneal with1ml single saline dose.Group2 (DMSO): Animals were administered orally with1ml of 6.5% DMSO for 19 days .Group3 (cisplatin): Animalswere injected intraperitoneal with cisplatin (10 mg/kg) as single dose to induce nephrotoxicity.Group4 (Gingeronly): Animals were administrated orally with 600 mg/Kg/day of ginger extract for 19 days. Group 5, 6and7: Animals pretreated with oral dose of ginger extract (200, 400 and 600 mg /kg/day respectively) for two weeks before and 5 days after single IP cisplatin (10 mg/kg). Administration cisplatin caused significant elevation in serum urea, creatinine concentration and kidney tissue levels of MDA and NO. Also caused significant increase in Caspase-3 levels, cisplatin significantly decreased level of Na. it decreased K, Mg and Ca level but statistically non-significant. Also it significantly decreased the antioxidant level of Catalase. Treatment with Ginger extract restored the levels of kidney concentration also oxidative stress markers in groups 5, 6 and 7 and alsodecrease Caspase-3 level. Alsohistopathological analysis confirmed that.Ginger extract have a protective role in cisplatin induced nephrotoxicity.