e -Issn : 0976 - 3651
Print-Issn : 2229-7480

  ABSTRACT

CURRENT INSIGHTS INTO PRE-ECLAMPSIA AND FUTURE STRATEGIES

Preeclampsia is a pregnancy disorder affecting 5-8% of pregnant women with 10% neonatal and perinatal mortality rate. Various factors play a key role in the occurrence of this disease which include immune system (systemic inflammatory response), inflammatory molecules and cytokines (oxidative stress, syncytiotrophoblast micro particles, IFN-γ and insulin like growth factors, tumor necrosis factor, angiogenic factors, heat shock protein ie.Hsp-70), Th1 and Th2 paradigm (switching to Th2 type immunity is restricted in preeclampsia), regulatory immune cells (Treg cells).All these factors contribute to the poor invasion of trophoblast resulting in poor placental development, poor placental perfusion and insufficient transport of nutrients. In this review, we highlight the role of various molecules/cells associated with the immune system and how their altered expression transforms an otherwise normal pregnancy in to a pregnancy-specific syndrome called Preeclampsia.

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