e -Issn : 0976 - 3651
Print-Issn : 2229-7480

  ABSTRACT

PHYTOCHEMICAL AND ANTI-CHOLINESTERASE OF LEAVES OF DIFFERENT HERBS ON FROG’S EXPERIMENTAL MODELS

The present study reports the preliminary phytochemical, anti-cholinesterase activity of leaves of the plant of Kigelia africana and Sophora interrupta. The shade dried powder of Kigelia africana (Bignoniaceae) and Sophora interrupta (Papilionaceae) was subjected to successive extraction using the solvents (Petroleum ether and Methanol) in the increasing order of polarity. Thus the prepared extracts were subjected to the preliminary phytochemical analysis. The extracts were investigated for anti-cholinesterase activity in green frogs which was compared with standard drug Neostigmine (1mg/ml). The parameter measured for anti-cholinesterase activity was ciliary movement in frog’s buccal cavity and degree of contraction of frog’s buccal cavity and degree of contraction of frog’s rectus abdominus muscle. Results revealed that the methanolic extract of the plants leaf showed significant anti-cholinesterase activity.

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