SOLID LIPID NANOPARTICLES: A NOVEL CARRIER FOR CANCER THERAPY
Recent advances in nanotechnology has shown incredible promise to alter cancer therapeutics by generating new therapies that might allow effective targeted delivery of anticancer drugs to kill cancerous cells and imaging agents for diagnosis of various cancers. Cancer a very critical disease occurs due to progressive accumulation of epigenetic and genetic changes causing death world wise. It is a class of disease characterized by rapid abnormal growth of cells in an uncontrolled way. The major disadvantage associated with anticancer drugs is their lacks of selectivity for tumor tissue, this result in severe side effects leads to low cure rates. Current available methods of cancer diagnosis and treatment are costly and can be very harmful to the body. At present, the most common cancer treatment methods are based on radiation therapy, chemotherapy, or surgery all of which can be successful, but have significant disadvantages. Modern nanotechnology, though, offers the possibility of materials that selectively bind to particular types of cancer cells, sensitizing them to light without affecting surrounding healthy tissues by selective targeting to tumor tissue. Solid lipid nanoparticles hold significant promise in cancer treatment. Many studies have been carried on SLN which proves to provide controlled drug delivery, targeting of drugs, enhancement of bioavailability of entrapped drugs, improvement of tissue distribution and incorporation of both lipophilic and hydrophilic drugs. This review article describes usefulness of solid lipid nanoparticle technology in cancers for targeted drug therapy.