FORMULAION OF TINIDAZOLE LIQUISOLID TABLETS AND INVITRO EVALUATION
This study was carried out to increase the solubility characteristics of experimentally developed tinidazole liquisolid tablets and do invitro studies. “Powdered solution technology†or “Liquisolid technologyâ€, is a more recent technique which enhance the solubility of the poorly water-soluble drugs by improving wettability and surface area. A liquisolid system is formed by converting a liquid formulation into a dry, free-flowing and compressible powder mixture with selected carrier material and coating material. In BCS classification, class II and class IV drugs dissolve slowly, poorly, irregularly and so have serious challenges in drug delivery. To achieve the required delivery of the above classified drug liquisolid system were seem to be the best option. In this work a water insoluble drug has been chosen and microcrystalline cellulose (Avicel PH 101) as carrier powder and silica (Cab-O-Sil) as coating material at different powder excipient ratio (R). Polyethylene glycol 600 was used as liquid vehicle to prepare liquid medications with a fixed 100 % (w/w) drug concentration. Different liquid load factor, 0.43, 0.52 and 0.59 were employed. Finally, standard 5% croscarmellose sodium (Ac-Di-Sol) was used as a disintegrant and 1% magnesium stearate as a lubricant. Among the three formulations LS-2 formulation was successfully for good sustained release action and it was Tinidazole liquisolid tablet formulation by using 20:1 ratio of Powder excipient ratio (480 mg of Avicel and 24 mg of Cab-O-Sil) and 100% (w/w) tinidazole in PG 600 solvent was satisfying the requirement. This technique has industrial applications for low dose insoluble drugs.