ANTICONVULSANT ACTIVITY OF LEAF EXTRACT OF VIGNA RADIATA (L.) WILEZEK
Vigna radiata. (Fabaceae) a widely growing plant has been reported to possess number of medicinal properties. The purpose of the present study was to evaluate scientifically the anticonvulsant activity of Chloroform and Methanol extract of leaves of the plant Vigna radiata in albino Wistar rats on electrically and chemically induced seizures. The antiâ€convulsant activity of different extracts of Vigna radiata leaves was studied against seizures induced by maximal electroshock seizures (MES). In the MES test, the methanol extract (100 & 200mg/kg, i. p) Vigna radiata of leaves showed the most significant (p<0.01) anticonvulsant effect by decreasing the duration of Hind Limb Tonic Extension (HLTE), clones and also the duration of stupor phase than other extracts when compared to control group. The ED50 dose of Phenytoin (25 mg/kg, i.p) was used as standard. In conclusion it was realized that methanol extract (ED50 = 100 & 200 mg/kg, i.p) is more potent than other extracts in showing anti-seizure effects.