ANTIHYPERLIPIDEMICS: EFFECT OF APPLE CIDER VINEGAR ON LIPID PROFILES
Abnormal metabolism of lipids leads the elevated level of fatty substances largely cholesterol and triglycerides into blood stream results, hyperlipidemia. The lowering of lipid concentration in blood through dietary or drugs therapy seems to be associated with a decrease in the risk of cardio vascular disease. Apple cider vinegar is a home remedy which is widely taken by the people in Malaysia to reduce the body weight. In this present study, the apple cider vinegar (ACV) was prepared and evaluated for its antihyperlipidemic activity in rat models. Hyperlipdemia in the rats was induced by feeding high cholesterol diet (HCD). ACV (1ml/day) and standard drug, atrovastatin were orally administered to the animals in respective groups and fed with HCD for 14 days except normal control rats. After the treatment cholesterol, triglycerides, HDL-C, LDL and VLDL level in serum were estimated. The weight gain in hyperlipidemic rats was significantly reduced in ACV treated rats. A significant increase in reduced HDL-C level and significant decrease in the elevated level of TC, TG, LDL and VLDL were observed in ACV treated rats when compared to HCD fed rats. All the results were compared with standard drug, atrovastatin. The results concluded that the ACV has significant antihyperlipidemic activity in HCD induced hyperlipidemia