SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SUBSTITUTED PYRIMIDINE DERIVATIVES FROM 2-ACETYL-5- METHYLFURAN DERIVED CHALCONES
A number of 2,4,6-trisubstituted pyrimidines were reported to possess diverse biological activities like antimicrobial, antidepressant, analgesic, anti-inflammatory, anticancer, antiviral, anti leishmanial, anti-tubercular, anti-HIV and anti-malarial activities. However, pyrimidines with antimicrobial and anticancer activities are being reported increasingly and hence it was felt worthwhile to evaluate them for these activities. The finding that 2,4-diaminopyrimidines inhibit the growth of microorganisms by interfering with their utilization of folic acid led to an intensive search for anti-infective agents in this class of heterocyclic compounds. Synthesis and purification of 2,4,6-trisubstituted pyrimidines from the chalcones obtained from 2- acetyl-5-methylfuran and screen the synthesized pyrimidines for their antimicrobial activity will be finding way to synthesis of similar compounds for various biological activities in future prospective