FORMULATION AND IN VITRO EVALUATION OF NIFEDIPINE SUSTAINED RELEASE TABLET USING HPMC K100
Nifedipine is a calcium channel blocking agent. It works by interfering with the normal action of calcium in blood vessel constriction and heart muscle contraction and nerve conduction in the heart. The aim of the present work was to develop sustain release formulation of nifedipine and investigate the in vitro drug release. Tablets were prepared by wet granulation technique using different concentration of hydroxy propyl methyl cellulose (HPMC K100), Lactose, MCCP, Starch, PVP and their combination in different ratios to examine their influence on tablet properties and drug release profile. Tablets were evaluated by measurement of hardness, friability, content uniformity, weight variation, drug release pattern, and assay. Release studies were carried out using USP type II apparatus in 900 ml of 0.1N HCl. The amount of drug released was determined at 340 nm by UV-visible spectrophotometer. The result was concluded that nifedipine sustained release tablets using HPMC polymer as sustaining agent is having constant release for 12 hours. By observing dissolution profile of trials it conclude that the trial-4 was the better formulation of all the trials.