COMPARATIVE STUDY OF ENTERIC COAT POLYMERS IN DELAYED RELEASE SULFASALAZINE TABLET
The main aim of the work is to develop delayed release enteric coated tablet formulation of Sulfasalazine using different enteric coat polymer. Sulfasalazine delayed release tablet is used to increase bioavailability and to prevent acid degradation, delivering the drugs to its local site of action in the intestine. Core tablets of Sulfasalazine were prepared and evaluated. The the cellulose acetate phthalate, HPMC-P polymers were used to coat the core tablet. On the basis of weight gain and USP specification the tablets were coated. The design of enteric coating based on the transit time required for passage to the intestine and may be accomplished through coatings of sufficient thickness. In general these substances are anionic polymers or copolymers which are insoluble in acidic media but acquire water solubility at near neutral pH values due to ionization of functional groups along the polymer chain. The application of enteric coat in combination gives more satisfactory & desired effect. Due to combination, the enteric coat may have high cohesive and adhesive forces of attraction between the functional group. It is concluded that, the enteric coat polymer gives promising dosage form to target the organ and prevent the loss of drug