HYPOLIPIDEMIC ACTIVITY OF ETHANOLIC AND METHANOLIC EXTRACTS OF ECHINOCHLOA CRUS-GALLI IN TRITON INDUCED HYPERLIPIDEMIC MICE
Hyperlipidemia is a condition excess of fatty substances called lipids, largely cholesterol and triglycerides, in the blood. It is also called hyperlipoproteinemia because these fatty substances travel in the blood attached to proteins. This is the only way that these fatty substances can remain dissolved while in circulation. In the present study different extracts of Echinochloa crus-Galli grian were checked for their hypolipidemic activity. The aim of this study has been to investigate the possible hypolipidemic effect of Echinochloa crus galli grain ethanolic and methanolic extracts in triton (400 mg/kg b.w.) induced mice. A comparison was made between the actions of ethanolic and methanolic grian (400 mg/kg b. w.) extracts of Echinochloa crus galli and a known hypolipidemic drug Atorvastatin (10 mg/kg b.w.). In the present study, administration of Triton WR 1339 (TYLOXAPOL) to mice caused increased deposition of fat in liver and various blood vessels. Treatment of Echinochloa crus galli ethanolic and methanolic grains extracts protected against triton induced hyperlipidemia. When compare to ethanolic extract, methanolic extract shows significant decrease in blood serum Total cholesterol, triglycerides levels. When compare to methanolic extract, ethanolic extract shows significant decrease HDL, LDL, VLDL cholesterol levels. The results are also in concurrence with histopathological studies