FORMULATION AND EVALUTION OF MEDICATED SUPPOSITORY OF CLINDAMYCIN PHOSPHATE
The present study aim at the formulation and evaluation of Clindamycin phosphate suppository to achieve the better bioavailability thereby increasing its therapeutic efficacy. Suppositories are prepared by using different type of PEGs base by fusion method. Six different formulations using the PEGs base were prepared with different ratios. These suppositories were evaluated for different parameters such as Physical Appearance, weight variation, disintegration time, drug uniformity content, melting time, hardness, softening time, dissolution studies and stability studies were also conducted. Among the formulated PEGs suppositories, The studies revealed that the higher proportion PEGs 1500 or low molecular weight PEGs combination gave grater release and better dissolution behavior overall increases in following order F4< F3< F6< F5< F1< F2. The formulation F2 showed maximum dissolution of 99.99% in 30 min while Formulation F4 showed the lowest drug release that is 67.53 in 6 hr .Thus it can be concluded that the drug release from suppositories depend on type and composition of base used. Hence altering the composition it is possible to achieve suppositories formulation showing optimal drug release and therefore better bioavailability. The formulation F2 can be suggested as the most suitable formulation for rectal delivery of the drug.