ANTIUROLITHIATIC ACTIVITY OF METHANOLIC EXTRACT OF DRIED LEAVES OF GLOCHIDION VELUTINIUM USING ETHYLENE GLYCOL INDUCED RATS
Urolithiasis is the process of stone formation in the kidney, bladder, and/or urethra. Herbal drugs are reported to be effective in the treatment of urolithiasis with no side effects. The aim of our Study is to assess the effects of dried leaves of Glochidion velutinium (GV) as a preventive agent in experimentally induced urolithiasis model in rats. The efficacy of 250 and 500mg/kg GV extract was studied in 0.75% ethylene glycol and 1% ammonium chloride-induced urolithiasis for 21 days in rats. The levels of calcium, phosphorus, oxalate in both 24h-urine & kidney were measured. The levels of BUN, creatinine and uric acid in serum were also measured. Histopathological analyses in kidneys were also performed. The increased levels of stone forming constituents in the kidneys of calculogenic rats was also significantly reduced by using methanolic extract of dried leaves of GV. The results indicating that the dried leaves of GV have antiurolithiatic activity.