FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL PATCHS OF METOPROLOL TARTRATE
In the present context the buccal route ranks with oral treatment as the successful innovative research area in the drug delivery. However the success of a drug to be used for systemic delivery via buccal route depends mainly on the ability of the drug to permeate through buccal mucosa in sufficient quantities which can be achieved with the help of penetration enhancers. Metoprolol tartrate is the preferred drug because it has plasma half life of 3-4 hrs and has low bioavailability which is an essential condition for formulation of buccal patches. In this study, hydrophilic polymers like Gelatin, Na alginate were used in different concentrations. The result of present investigation stated that the Sod. Gelatin and Na Alginate have good matrix/film forming characteristics which was confirmed by the visual and physiological characterization of the patches. In-vitro and exvivo studies indicated that successful buccal patches of Metoprolol Tartrate could be prepared using hydrophilic polymers viz. Gelatin and Na Alginate employing solvent casting technique.