FORMULATION AND INVITRO EVALUATION OF ISONIAZID SLN NANOPARTICLE
The Present research work is to formulate and evaluate solid lipid nanoparticles containing Isoniazid by using solvent evaporation method. In the present investigation it was approached to develop a controlled release Solid Lipid Nanoparticle formulation containing Isoniazid with optimized particle size with the help of different concentration of polymer. It was concluded that Solvent evaporation method followed by ultrasonication was an optimized technique for the preparation of SLN nanoparticle, which lead to better results like high entrapment efficiency, good percentage yield, high drug content and Span 60 was a better choice of surfactant to reduce the particle size and leads to uniform distribution of SLN in its phase