HEPATOPROTECTIVE ACTIVITY OF CANAVALIA GLADIATA ROOT EXTRACT ON D-GALACTOSAMINE INDUCED HEPATIC DAMAGE
Canavalia gladiata root extract was evaluated for Invivo hepatoprotective activity against D-galactosamine induced hepatic damage. Canavalia gladiata (Fabaceae) roots were extracted with hydroalcohol to prepare extract. The hepatoprotective activity of hydroalcoholic canavalia gladiata extract was assessed against D-galactosamine (D-GalN) at different dose levels. Then in vivo hepatoprotective of canavalia gladiata at dose 200 and 400 mg/kg body weight was carried out against D-GalN, which on dose of 400 mg/kg body weight i.p induces liver damage in rats. The phytochemical screening on canavalia gladiata roots revealed the presence of primary metabolites such as, carbohydrates and proteins, the secondary metabolites such as alkaloids, glycosides, saponins, flavonoids, phenolic compounds and tannins. The D-GalN intoxicated animals showed a significant increase in the levels of SGOT, SGPT, ALP, TC, TB and TGL and decrease in liver weight, TP and albumin when compared to the normal. All the biochemical parameters were attenuated to near normal level on treatment with the canavalia gladiata extract. These findings concluded that canavalia gladiata root extract protects the liver from severe damage caused by D-GalN and may serve as a useful adjuvant in several clinical conditions associated with liver damage