IMPROVED ORAL ABSORPTION OF CARBAMAZEPINE FROM SORBITAN MONOLAURATE BASED PRONIOSOME SYSTEMS CONTAINING CHARGED SURFACE LIGANDS
Drug administration via oral route is most popular but the limiting factor for oral delivery is poor bioavailability. Colloidal drug delivery systems appear to resolve the problems of oral bioavailability in totality. Though liposomes and niosomes have been studied extensively for drug delivery via various routes, their use in oral delivery was not successful. Due to physical and chemical stability problems associated with vesicular dispersions, provesicular products were developed. Carbamazepine (CBZ) is used in the treatment of epileptic and psychotropic disorders. Absorption of CBZ from the gastrointestinal tract is slow and erratic. CBZ was incorporated into proniosomal systems containing charged and surface ligands. The particle size of these was found to be in nanorange with % entrapment of more than 95. The proniosome systems were evaluated for In situ absorption study. In situ absorption data revealed that proniosomal-CBZ promote significant enhancement in oral absorption of CBZ. Among the charged ligands, positively charged system showed maximum absorption enhancement effect. This could be due to nano size of vesicles and positive charge on their surface.