COMPARATIVE PHARMACOKINETIC PROFILE OF TINIDAZOLE COLON TARGETED FORMULATION WITH AN IMMEDIATE RELEASE FORMULATION
The aim of the present investigation was to compare pharmacokinetic profile of Tinidazole colon targeted formulation with an immediate release formulation of Tinidazole. The formulated colon targeted tablet and a marketed immediate release tablet were subjected to pharmacokinetic (bioavailability) evaluation following an oral dose of 30 mg of drug per kg body weight of healthy rats. Several pharmacokinetic parameters like Cmax, Tmax, AUC0→t, AUC0→∞, Ke and T1/2 were determined from plasma concentration-time profile of all formulations. The absorption of Tinidazole marketed immediate release tablet and formulated colon targeted tablet resulted in1.29 and 2.42 fold increase in bioavailability respectively as compared to pure Tinidazole drug administered as such. Results of these studies indicate that the formulated colon targeted tablet can be successfully used as a vehicle for enhancement of bioavailability of Tinidazole. Further the pharmacokinetic parameters indicated that the formulated colon targeted tablet exhibited prolonged effects of Tinidazole in rats.