FORMULATION AND EVALUATION OF IR IBUPROFEN TABLET BY USING (APOC) GRANULATION TECHNIQUE
Agglomerative phase of comminution (APOC) is a relatively newer granulation cum particle size reduction technique in which agglomeration of the fine coherent particles take place into loose granular structure. Agglomeration of the fine cohesive particles produced during grinding particularly with rotating or oscillating ball mills. Reduction of particle size during prolonged grinding by a ball mill has been used as a novel means of producing a pharmaceutical granulation. When compared with conventional granulation methods, this method produced mechanically stronger tablets with a higher dissolution rate than those compacted from granules made by a conventional wet granulation method. It is suggested that binderless tablets may be prepared by using this method, thus simplifying tablet formulation and enhancing stability. A possible mechanism for the increased dissolution rate is the increased internal surface area of the particles produced by the prolonged grinding method. As the comminution proceeds, agglomeration commences and eventually a wide size range of particles is produced consisting essentially of very coarse and very fine particles. This system eventually comes to an equilibrium situation, where coarse particles are milled to produce fine powder which, in turn, coheres to form coarse granules. Increased homogeneity and bioavailability characteristics can be obtained both by of this granulation technique