FORMULATION AND EVALUATION OF TRANSDERMAL PATCHE CONTAINING ANTI-INFLAMMATORY DRUG OF LORNOXICAM
Transdermal patches of Lornoxicam were developed with different ratios of hydrophilic (SCMC) and hydrophobic (EC) polymer combinations by solvent evaporation technique. The Fourier transform infrared (FTIR) spectroscopy was used to confirm compatibility and to rule out any possible interactions between drug and polymers. Seven transdermal patch formulations (F1, F2, F3, F4, F5, F6 and F7) consisting SCMC and EC in the ratios of 5:0, 0:5, 1:1, 4:1, 1:4, 3:2, 2:3 respectively were prepared. All formulations carried 4 % w/v of Tween 80 as penetration enhancer and 10 % w/v of PEG 400 as plasticizer in dichloromethane and methanol (4:1) solvent system. The prepared patches were evaluated for their physicochemical characteristics such as physical appearance, weight variation, thickness, folding endurance, percentage moisture absorption, percentage moisture loss, water vapour transmission, tensile strength and drug content and in vitro drug release studies. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. Combination of polymers SCMC and EC (1:1) showed better release for sufficiently long time and emerged to be ideal formulations for Lornoxicam. The developed transdermal films prolonged release for 24 hrs and thus found useful to improve the patient compliance of Lornoxicam