DENDRITIC NANOPARTICULATED CARRIERS FOR THE DELIVERY OF ANTI TUBERCULOSIS BIOACTIVES
The present study was aimed at developing and exploring the use of PPI dendrimers for delivery of anti-tuberculosis drug, Rifampicin (RMP). RMP was selected for incorporation into dendrimers based on its antitubercular activity, short biological half-life and solubility characteristics. For this study, poly (propyleneimine) dendritic architecture was loaded with Rifampicin.Various physicochemical and physiological parameters like UV, FT-IR, TEM, DSC, zeta potential, drug entrapment and drug release of formulations were determined. By constructing drug release kinetics, the release mechanism followed was a non fickian diffusion. In this, the system was found to have increased their drug-loading capacity, reduced their drug release rate. Therefore the system was found to be suitable for prolonged delivery of Rifampicin