METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TRAZODONE HCL BY UV SPECTROSCOPY IN PHARMACEUTICAL DOSAGE FORM
A simple and sensitive UV spectrophotometric method has been developed for the estimation of trazodone hydrochloride in bulk and tablet dosage form. The stock solutions were prepared in acetonitrile followed by further required dilutions with distilled water. This method involves the formation and solving of equations at 247 nm as absorbance maxima of trazodone hydrochloride. Beer’s law obeyed that the concentration range of 2–10µg/ml. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the estimation of this in bulk and in combined tablet dosage form