STUDY ON MATRIX METALLOPROTEINASES IN DIABETIC FOOT ULCER DISEASE
The aim of this study is to compare the level of matrix metalloproteinases in diabetic and non-diabetic foot ulcer disease patient‟s plasma and tissue sample. Cross-sectional study: we studied a group of adults with T2DM (n=10) and another group of adults without T2DM (n=6). MMPs in plasma and tissue samples were detected by gelatin zymography. The plasma and tissue concentrations of MMP-9 and MMP-2 and non-enzymatic antioxidants were found to be increased in diabetic foot ulcer patients compared to non-diabetic foot ulcer patients. The elevated levels of MMP-9 and -2 in chronic ulcer subjects, delays wound healing process by degrading the extracellular matrix materials in an uncontrolled way. This study provides evidence for the role of MMPs 2 and 9 in diabetic foot ulcer disease