AGAIN TO THE SPECIFICITY OF COUMARINS
The aim of the present investigation was to evaluate the effect of coumarin, 6,7-dihydroxycoumarin, 5,7-dihydroxy-4- methylcoumarin and 7,8-dihydroxy-4-methylcoumarin on the ROS-emission by different tumor cells (human epithelial colorectal carcinoma HT-29, breast cancer epithelial-like morphology MDA-MB-231, epithelial cervix adenocarcinoma HeLa and hepatocellular liver carcinoma HepG2.). Such effects were observed by means of the antiproliferative MTS-test. The data varied for the different cell lines and depended on the particular coumarin derivative. The antioxidant properties of coumarins were examined by HORAC (HO•-radical) and ORAC (RO2•-radical)