FORMULATION AND EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY OF CEFIXIME USING RAFT FORMING APPROACH
There has been increased demand for the Novel Dosage Forms to gain more patient compliance. The bactericidalaction of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the Penicillin binding protein. Tablets of Cefixime were prepared by Direct compression method by using various polymers like HPMC K 15M, Guargum, Chitosan, Micro crystalline cellulose as binder, Sodium bicarbonate was incorporated as an effervescent substance, Sodium alginate used as viscous gel forming agent, Magnesium Streate as lubrication, Talc was used as diluents. By using Raft Forming Approach above prepared Tablets of Cefixime were converted into Gastro Retentive Formulations. There by residing time of formulation in the stomach was increased. Longer residence time in the stomach could be advantageous for local action in the upper part o f the small intestine, for example treatment of bacterial infections. FTIR spectroscopy study reveals that no inter actions between drug and polymers, F1-F9 formulations were developed, and evaluated for thickness, weight variation, friability, drug content, floating time, lag time and in-vitro drug release. The floating time and lag time for the optimized formulation F7 was found to be 18 sec and 12hrs respectively. In-vitro drug released was found to be 97% for F7