SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF ISATIN DERIVATIVES
Some new Synthesis of (N-carbamimidoyl 1-4-(2-oxo-1-(piperidine-1-ylmethyl) indolin-3-ylidineamino) benzene sulphonamide) has been synthesized from isatin & different p-substitute aniline. In the next step, I (a-h) on treatment with isatin, sulfanilamide and reflux with glacial acetic acid Synthesis of carbamimidoyl - 3 – (2-oxo-indalin-3 – yl- indene amino) benzene sulphonamide (a-h) In the last step, which on mannich reaction with piperidine and formaldehyde gave(Ncarbamimidoyl 1-4-(2-oxo-1-(piperidine-1-ylmethyl) indolin-3-ylidineamino) benzene sulphonamide) (a-h) under microwave irradiation at a power of 140 watts. MW irradiation led to higher yields in much less time than that by conventional method. The newly synthesized compounds were characterized on the basis of elimental analysis, IR, H NMR, and mass spectra. All the synthesized isatin derivatives have been investigated for their anti-inflammatory activity.