GALACTAGOGUE ACTION OF THE CRUDE PHENOLIC EXTRACTS OF GRAPE SEEDS (VITIS VINIFERA)
The galactagogue action of the crude phenolic extracts of the grape seed (Vitis vinifera) was studied in mice. The crude phenolic extract of Vitis vinifera seeds in a dose of (100,200 and 400 mg/kg bw) was significantly (p<0.001), (p<0.0001) and (p<0.0001) increased serum prolactin level in a dose dependent manner, the maximum effect was recorded when the crude phenolic extract used in a dose of 400mg/kg bw. The weight of the litter of the females treated with 400mg/kg bw of the crude phenolic extract of Vitis vinifera seeds, was significantly (P<0.05) higher than those of female of control group. However, the weight of the litter of the females treated with 100 and 200 mg/kg bw of the crude phenolic extract of Vitis vinifera seeds didn’t showed significant changes compared with the weight of litter of mothers of control group. The section of the mammary tissue of the mice treated with crude phenolic extract of Vitis vinifera seed showed larger acini, thicker epithelia, and more secretory activity, compared to the mammary tissue of the lactating mice in the control group