SYNTHESIS OF AZOMETHINE DISELENIDES: A NEW CLASS OF POTENT ANTIOXIDANTS
Azomethine diselenides were prepared by a simple and convenient method employing non-cryogenic condition. The diselenide anion, Se 2 2-formed by reducing elemental selenium with 100% hydrazine hydrate in sodium hydroxide as a base reacts insitu with 2-bromobenzaldehyde followed by the condensation with arylamines to affords the title compounds in moderate to good yields. The newly synthesized compounds were characterized by spectral and elemental analysis and further screened for their abilities towards antioxidant activity using well documented in vitro assays. Among the synthesized compounds, 3i bearing di-hydroxy group on the phenyl ring and 3j bearing methoxy group addition to phenolic moiety showed dominant antioxidant activity compare to standard BHA