SOLATION, CHARACTERIZATION AND SCREENING OF ANTIMICROBIAL METABOLITES FROM DESERT ACTINOBACTERIA STREPTOMYCES SP. STRAIN DA7-2
An antimicrobial bioactive metabolites producing actinobacterial strain DA7-2 was isolated from desert soil samples. Based on morphological and biochemical characterization, the isolate was identified as Streptomyces sp. strain DA7-2. Based on the media selection, modified nutrient glucose medium was selected for the production of bioactive metabolites. Ethyl acetate extract of DA7-2 exhibited good antimicrobial activities against pathogenic bacteria such as K. pneumoniae (15 mm), E. faecalis (11 mm), E. coli (13 mm), S. typhimurium (12 mm), P. aeruginosa (8 mm), S. aureus (18 mm) and fungi such asC. albicans (8 mm)C. neoformans (12 mm) and S. cerevisiae (17 mm). Based on the results of antimicrobial activity against pathogenic microorganisms, it is clear that the actinomycetes from desert soil environs are promising source for discovery of new antimicrobial compounds