EVALUATION OF WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF GREWIA ASIATICA L. AGAINST DIABETIC FOOT ULCER IN STREPTOZOTOCIN INDUCED DIABETIC RATS
The aim of the present study was to estimate the excision wound healing effect of methanol extract of inner bark of Grewia asiatica L. (MEGA) on Streptozotocin-induced diabetic rats. The wound healing activity was evaluated by Excision model. After overnight fasting, 24 rates were induced diabetes mellitus by giving a single injection of streptozotocin (45 mg/kg, i.p.) prepared by dissolving in 0.9% ice cold citrate buffer (pH 4.5). In Excision model, standardized wound area (2 mm × 5 mm skin in full thickness removed) was induced on the dorsal surface of the right hind foot of rats. Excision wound was induced in diabetic as well as normal rats. Wound healing parameters like percentage wound contraction, period of epithelialization were observed by administering standard bacitracin ointment and MEGA (10% and 20% w/w) topically. The MEGA afforded significant wound healing potential in diabetic rats which may be due to the presence of phytochemical constituents such as flavonoids and sterols.