ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ETHANOLIC EXTRACT OF ARISTOLOCHIA INDICA ROOTS IN STREPTOZOTOCIN - NICOTINAMIDE INDUCED DIABETIC RATS
The aim of the present study was done to evaluate the antihyperglycemic, antihyperlipidemic activities of ethanolic extract of Aristolochia Indica Linn root (EEAI) in streptozotocin (STZ) - nicotinamide (NC) induced diabetic rats. Antihyperglycemic effect was assessed in EEAI using diabetic rats (200 and 400 mg/kg) and glibenclamide (5 mg/kg) orally administered daily for 28 days. Fasting blood glucose (FBG) and body weight was determined weekly basis up to 28 days. On the 28th day, various biochemical parameters were estimated. The two doses of EEAI shows significantly decrease (p<0.01) in blood glucose levels. The effect was more pronounced in 400 mg/kg (66.11%) than 200 mg/kg (64.98%). In addition, decreased HbA1C and improved Hb level were evidenced clearly in diabetic rats. Simultaneously, improvements in serum lipid profile, serum liver profile in diabetic rats were also evidenced clearly. Moreover, body weight was increased in diabetic rats. The EEAI is capable of managing hyperglycemia and complications of diabetes in STZ - NC induced diabetic rats. Hence this plant may be considered as one of the potential sources for the isolation of new oral antihyperglycemic agent(s).