METHOD DEVELOPMENT AND VALIDATION OF LAMIVUDINE AND EFAVIRENZ IN HUMAN PLASMA BY LC-MS/MS
Comparative bioavailability studies permit judgement as to the bioequivalence of Drugs. The determination may in turn lead to important decision related to Drug product selection by pharmacists. However it should be noted that neither bioavailability nor bioequivalence data could be generated without analytical methodology to accurate measure Drug in biological fluids. The developed and validated bioanalytical method for Lamivudine and Efavirenz drugs shows satisfactory linearity, precision, accuracy and stability. The method can be particular useful for pharmacokinetics and pharmacodynamics