DESIGN AND DEVELOPMENT OF HPMC-GELATIN BASED INSITU GELS OF KETROLAC AND THEIR INVITRO EVALUATION
Drug delivery technologies alter the profile of a drug's release, absorption, distribution, and elimination in order to improve the efficacy and safety of the product, as well as patient convenience and compliance. Numerous ocular vehicles have been created, including inserts, ointments, suspensions, and aqueous gels, in order to prolong the residence period of the implanted dosage and increase ophthalmic bioavailability. On the basis of the approach used to initiate the sol-to-gel phase transition on the eye surface, three types of insitu gelling ocular delivery systems have been developed: pH-triggered systems, temperature-dependent systems, and ion-activated systems. The purpose of this work is to attempt the development of an ophthalmic in-situ gel of Ketrolac. The infrared spectrum revealed no interaction between the drugs and the polymers. All polymers utilised were non-toxic to either drug. To create the opthalamic in-situ gels, a simple mixing procedure known as chilling was used. In-situ gel properties such as pH, capacity, clarity, drug content, and viscosity were evaluated, as well as in-vitro drug release experiments. All parameters were determined to be within their specified limits. According to the data collected, among the numerous combinations of polymers employed in the study, in-situ gels made with Gelatin (0.6gms) and HPMCK10 (0.5gm) displayed superior outcomes than those produced with other combinations of polymers in varying concentrations