IN-VITRO EVALUATION OF ANTIOBESITY ACTIVITY OF PARMOTREMA TINCTORUM
Obesity is a chronic disorder caused by an imbalance between energy intake and expenditure in which excessive fat will be deposited in adipose tissue and poses a risk to the health and well-being of human. Agents that inhibit pancreatic lipase play an important role in the treatment of obesity. The aim of this study was to assess the potential effect of Parmotrema tinctorum, foliose lichen in the treatment of obesity. In-vitro antiobesity pancreatic lipase inhibitory effect of methanolic extract of Parmotrema tinctorum was evaluated by lipase extracted from bovine pancreas. Different concentrations of methanolic extract of Parmotrema tinctorum and standard Orlistat i.e., 5-25 mg/ml was incubated with pancreatic lipase. With the increase in the concentration of extract, the higher inhibition of the enzyme was observed. Methanolic extract of Parmotrema tinctorum (MEPT) showed good inhibition activity. Percentage of inhibition ranged from 6.95% to 51.30% with the extract. Maximum inhibition was shown at 25 mg/ml concentration