ASSOCIATION OF SERUM URIC ACID LEVELS WITH CLINICAL OUTCOMES, COMPLICATIONS, AND PROGNOSIS IN PATIENTS SUFFERING FROM ACUTE MYOCARDIAL INFARCTION: A COMPREHENSIVE CORRELATION STUDY
Clinical and epidemiological studies have demonstrated a significant correlation between serum uric acid (SUA) levels and cardiovascular diseases. High uric acid levels have been suggested as a negative prognostic factor in patients with myocardial infarction (MI), with evidence linking elevated SUA to increased mortality risk. However, uncertainty remains regarding the precise role of uric acid in acute coronary syndrome and its potential utility as a prognostic marker in MI patients. Objective: This study aims to evaluate the association between SUA levels and clinical outcomes in patients with myocardial infarction, including severity, treatment response, ejection fraction, arrhythmias, and hypotension. Methods: A total of 100 patients diagnosed with MI were recruited from Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India. Detailed history-taking and clinical examination were conducted. Serum uric acid levels were measured and correlated with various clinical parameters, including ejection fraction, Killip classification, and other cardiovascular outcomes. Results: The mean age of the study participants was 56 years, with a mean SUA level of 5.9 mg/dL. The cohort comprised 65% males and 35% females, with males exhibiting significantly higher SUA levels than females (p < 0.05). Patients with SUA levels >7 mg/dL (n = 17) had significantly lower ejection fractions (p = 0.03). Additionally, among 15 patients classified as Killip IV, 12 had SUA values exceeding 7 mg/dL (p < 0.05). Conclusion: Elevated SUA levels are strongly associated with adverse outcomes in MI patients, including reduced ejection fraction and higher Killip classification. Measuring SUA levels at admission in acute MI patients may aid in risk stratification and guide early and targeted therapeutic interventions. SUA is a significant independent risk factor for myocardial infarction and stroke.